Your first 90 days on a GLP-1
Week by week: what the starter dose actually feels like, when appetite changes show up, when your provider will titrate, and the three weeks most people find hardest.
Longevity · Daily
NAD+ Nasal Spray
Daily NAD+ without needles. Lower bioavailability than injection, far easier to actually keep doing.
Pricing confirmed on your consultation
Your consult is free. We will not prescribe this — or anything — before a clinician has spoken with you and reviewed your bloodwork. Final cost depends on the form and dose prescribed.
Compounded · Rx only
Mechanism
Convenience that compounds.
Intranasal delivery absorbs NAD+ through the nasal mucosa, avoiding first-pass metabolism in the liver that limits oral forms.
Bioavailability sits below injection but well above oral capsules. For daily maintenance the adherence advantage usually matters more than peak levels.
Many patients load with injections and maintain with the spray.
Protocol
How treatment usually runs.
A typical schedule. Yours is set by your clinician after your labs come back.
| Phase | Weeks | Typical | Purpose |
|---|---|---|---|
| Start | 1–2 | One spray per nostril daily | Assess tolerance. |
| Maintenance | 3+ | One to two sprays daily | Adjusted to response. |
What to expect
Honestly, over time.
Week 1
Tolerance
Mild nasal irritation is the usual early complaint.
Week 2–4
Energy
Where responders typically notice change.
Month 2–3
Steady state
Consistency matters more than dose here.
Ongoing
Reassess
Your provider reviews whether it is worth continuing.
Evidence
What the research shows.
Intranasal NAD+ achieves higher bioavailability than oral supplementation while avoiding injection.
As with all NAD+ therapy, human outcome data remains early and reported benefits are largely subjective.
Safety and eligibility
Your consult and labs screen for all of the following.
- Common side effects include nasal irritation, dryness and mild headache.
- Not recommended during pregnancy or breastfeeding.
- Compounded — not FDA-evaluated for safety, efficacy or quality.
FAQ
NAD+ Nasal Spray questions.
Bioavailability is lower than injection but considerably higher than oral capsules. For daily maintenance, the ease of actually taking it consistently often outweighs the difference in peak levels.
Many patients do — injections to load, spray to maintain. Your provider will set the combined schedule.
Patients who respond usually notice energy changes in the second to fourth week of consistent daily use. If nothing has changed by month three, it is reasonable to stop.
We will not prescribe before we understand you.
Book a one-to-one consult with the clinical team. We talk through your goals, order the bloodwork that matters, and build a plan from what we find.