Your first 90 days on a GLP-1
Week by week: what the starter dose actually feels like, when appetite changes show up, when your provider will titrate, and the three weeks most people find hardest.
Hormones · Women
Estrogen & Progesterone
Hormone therapy for perimenopause and menopause, dosed to symptoms and labs rather than to a protocol you were handed on the way out the door.
Pricing confirmed on your consultation
Your consult is free. We will not prescribe this — or anything — before a clinician has spoken with you and reviewed your bloodwork. Final cost depends on the form and dose prescribed.
Compounded · Rx only
Mechanism
Replacing what declined.
As ovarian function declines, falling estrogen drives hot flushes, night sweats, sleep disruption, vaginal dryness, mood change and accelerated bone loss.
Estrogen therapy addresses those directly. Progesterone is added for anyone with a uterus to protect the endometrium — this is not optional.
Route matters. Transdermal estrogen carries a lower clot risk than oral, which is often the deciding factor.
Protocol
How treatment usually runs.
A typical schedule. Yours is set by your clinician after your labs come back.
| Phase | Weeks | Typical | Purpose |
|---|---|---|---|
| Baseline | Week 0 | Labs and history | Including clot and cancer risk review. |
| Start | 1–8 | Lowest effective dose | Transdermal preferred where clot risk exists. |
| Review | 8–12 | Symptom check and adjust | Dose titrated to symptom control. |
| Maintenance | 3+ months | Reviewed annually | Ongoing risk-benefit reassessment. |
What to expect
Honestly, over time.
Week 2–4
Vasomotor relief
Hot flushes and night sweats usually respond first.
Week 4–8
Sleep and mood
Often follow once night sweats settle.
Month 3
Vaginal and urinary
Tissue changes take longer.
Ongoing
Bone protection
A long-term benefit, not something you feel.
Evidence
What the research shows.
Hormone therapy is the most effective available treatment for vasomotor symptoms of menopause and reduces the rate of bone loss.
Risk depends heavily on age, time since menopause, route and personal history. This is a genuinely individual decision, not a blanket yes or no.
Safety and eligibility
Your consult and labs screen for all of the following.
- Do not use with a history of breast cancer, estrogen-sensitive cancer, unexplained vaginal bleeding, or active clotting disorder.
- Progesterone is required alongside estrogen for anyone with an intact uterus.
- Transdermal routes carry lower clot risk than oral and are preferred where risk exists.
- Report immediately any unexplained vaginal bleeding, leg swelling or chest pain.
FAQ
Estrogen & Progesterone questions.
For most healthy women within ten years of menopause onset, benefits generally outweigh risks. Risk rises with age, time since menopause and personal history of clots or hormone-sensitive cancer. It is an individual assessment, not a blanket answer.
If you have a uterus, yes. Unopposed estrogen increases endometrial cancer risk. Progesterone protects the uterine lining and is not optional in that situation.
Hot flushes and night sweats often improve within two to four weeks. Sleep and mood typically follow. Vaginal and urinary symptoms can take up to three months.
We will not prescribe before we understand you.
Book a one-to-one consult with the clinical team. We talk through your goals, order the bloodwork that matters, and build a plan from what we find.